Diabetes Research

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Inactivation of NF-κB p65 (RelA) in Liver Improves Insulin Sensitivity and Inhibits cAMP/PKA Pathway

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http://diabetes.diabetesjournals.org
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Too Much or Too Little? The Double Jeopardy of Subcutaneous Insulin Therapy in Diabetes

A quote variously attributed to either Woodrow Wilson or Winston Churchill describes golf as “an ineffectual attempt to putan elusive ball into an obscure hole with implements ill-adapted to the purpose.” There are many analogies with the challengesfa ...

http://diabetes.diabetesjournals.org
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Kallikrein-Kinin System: An Emerging Competitor or Collaborator for VEGF in Diabetic Macular Edema?

An increasing number of patients with diabetes suffer from vision-threatening diabetic retinopathy (DR), i.e., proliferativediabetic retinopathy (PDR) and diabetic macular edema (DME), worldwide (1). Vascular endothelial growth factor (VEGF) plays a k ...

http://diabetes.diabetesjournals.org
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Alternative Approach to Immunomodulation for Type 1 Diabetes: Antigen-Specific Immunotherapy In Utero

Type 1 diabetes (T1D) results from the T-cell–mediated destruction of insulin-secreting pancreatic β-cells (1). While we can treat this condition with insulin replacement, long-term outcomes for patients is suboptimal (2), and a “cure” for T1D is a ve ...

http://diabetes.diabetesjournals.org
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Paying the Toll for Glucose Regulation: A Central Role for TLR3

Innate immunity is now known to impact tissue metabolic responses with members of the Toll-like receptor 2 and 4 (TLR 2/4)family implicated in dyslipidemia. However, the impact of other TLR proteins on metabolic regulation has remained poorly understo ...

http://diabetes.diabetesjournals.org
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Defective Wnt Signaling: A Potential Contributor to Cardiometabolic Disease?

Hypertension is a major public health problem associated with the increased risk for heart disease and stroke, leading causesof death worldwide. Despite recent treatment advances, hypertension remains present in approximately one-third of adults inthe ...

http://diabetes.diabetesjournals.org
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Unsticking the Broken Diabetic Heart: O-GlcNAcylation and Calcium Sensitivity

Cardiovascular disease is the leading cause of death in patients with diabetes. However, identifying mechanisms of diseaseprogression has proven difficult as diabetes involves dysfunction of numerous pathways including cellular signaling and mitochond ...

http://diabetes.diabetesjournals.org
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In This Issue of Diabetes

By Max Bingham, PhD ...

http://diabetes.diabetesjournals.org

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